There is something quite surreal about the start to this film.... The opening sequence features a gang of outlaws chasing a gold shipment, but it's being carried on a bus - an ordinary coach with passengers merrily trundling down the highway as the baddies give pursuit on horseback! At this point a charismatic and handsome John Wayne and the "Mesquiteers" hit on an idea to buy an aeroplane to fly said bullion in safety in future. Needless to say, the owner of the shipping company is none to pleased at the progress and so brings in some muscle to put the kibosh on their cunning plan. Silent film star Louise Brooks provides the glamour, and all told it's quite a jolly little adventure film with nothing much of note in the plot or the script aside from the slightly odd cross-over aspect that signalled the permanent decline of this genre as an appreciably relevant way of life for many who would still have actively recalled the ways of the old west.
David Ross organizes the ranchers into a vigilante group to rid the town of outlaws. The plan succeeds but the trouble starts when some of the men form a new vigilante group and posing as the original one plunder for loot.
When Professor Marsh disappears while searching for the lost city of Lukachukai, his daughter enlists the help of the Three Mesquiteers.
A crooked real estate manipulator sells worthless land on mortgage to flood refugees, then tries to profit by reselling the land to the state, committing murder in the process, as the Three Mesquiteers work to bring him and his gang to justice.
The year is 1949. A young Texan named John Grady finds himself without a home after his mother sells the ranch where he has spent his entire life. Lured south of the border by the romance of cowboy life and the promise of a fresh start, Cole and his pal embark on an adventure that will test their resilience, define their maturity, and change their lives forever.
A banker struggles to keep his bank solvent and his town from going bankrupt after the bank is robbed and all its money taken. The Three Mesquiteers ride into town and set out to help.
The Three Mesquiteers convince a group of settlers to exchange their present property for some which, unbeknownst to our goodguys, is going to be worthless. They are captured before they can warn the ranchers.
Bickford Waner, an apparently naive young man from Fort Worth, arrives in the tiny Texas town of Dime Box and takes on a variety of menial jobs. He's befriended by Reese Ford and his wife Molly, but before long Molly has seduced Bickford. Only with the arrival of Bickford's former girlfriend Janet Conforto is it revealed that Bickford is actually the notorious train robber Kid Blue. Humiliated by a scandal arising from his affair with his friend's wife, Bickford gives up on going straight and plots a crime.
The Cattlemen's Association has called in the Mesquiteers to find cattle rustlers. They get Tex Riley to pose as Stony so Stony can arrive posing as a wanted outlaw. This gets Stony into the gang of rustlers and he alerts Tucson and Lullaby as to the next raid. But Hartley is on hand and unknown to anyone is the rustler's boss and he joins the posse with a plan that will do away with the Mesquiteers.
Unable to legally capture and sell a herd of protected wild horses, corrupt rancher Rance Macgowan uses his trained killer horse, Volcano, to substitute for the real leader of the herd and cause havoc and death among the ranches. With the government about to drop the restrictions on rounding up the herd, the Three Mesquiteers find themselves in the middle of the controversy after their friend, Sheriff Miller is killed by Volcano.
To fight a poisonous weed, ranchers are burning their land. Gene is the Inspector brought in and he recommends spraying. The spraying goes well until the Larabee ranch is reached. When Larrabee refuses to allow the equipment on his land, Gene has it sprayed by airplane. Cattle must stay off recently sprayed land and when a Larrabee man shoots down the plane, the crash sends the cattle stampeding toward the newly sprayed land.