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Frankenstein's unscrupulous colleague, Dr. Bohmer, plans to transplant Ygor's brain so he can rule the world using the monster's body, but the plan goes sour when he turns malevolent and goes on a rampage.
Blackmailing a young couple to assist with his horrific experiments the Baron, desperate for vital medical data, abducts a man from an insane asylum. On route the abductee dies and the Baron and his assistant transplant his brain into a corpse. The creature is tormented by a trapped soul in an alien shell and, after a visit to his wife who violently rejects his monstrous form, the creature wreaks his revenge on the perpetrator of his misery: Baron Frankenstein.
Baron Victor Frankenstein has discovered life's secret and unleashed a blood-curdling chain of events resulting from his creation: a cursed creature with a horrid face — and a tendency to kill.
Dr Simon Helder, sentenced to an insane asylum for crimes against humanity, recognises its director as the brilliant Baron Frankenstein, the man whose work he had been trying to emulate before his imprisonment. Frankenstein utilises Helder's medical knowledge for a project he has been working on for some time. He is assembling a man from vital organs extracted from various inmates in the asylum. And the Baron will resort to murder to acquire the perfect specimens for his most ambitious project ever.
Rescued from the guillotine by his devoted dwarf Fritz, the Baron relocates to Carlsbruck, where he continues his gruesome experiments.
Journalist Mike Harway decides to help his friend Christine in her search for her father, professor Baker, who mysteriously disappeared. The investigation brings them to Africa where they are captured and brought to the El Faium abandoned fort. It now hosts a laboratory designed by the twisted mind of Devilman, who dreams of swapping his natural brain with an artificial one that will make him perfect.
The discovery of a perfectly preserved caveman prompts a mad scientist to attempt a daring brain transplant.
University professor George Kingsley is struck by gangsters while crossing the street, leaving him with brain damage and one of the gangsters, Cannon, paralyzed. Kingsley's friend Dr. Sovac attends to both men, and when Cannon offers him a reward for aiding his recovery, Kovac transplants part of Cannon's brain into the dying Kingsley's skull, creating a dual personality.
A rich but unscrupulous old woman plots with a scientist to have her brain implanted in the skull of a sexy young woman.
Amir, the benevolent ruler of Kalid, is dying, but there is hope. Freshly deceased, he is flown to the United States where Dr. Trenton transplants his brain into the body of a simpleton in a classic "assistant got the wrong kind of body" plot line. Dr. Trenton has a few nefarious plot twists of his own in mind, and then there's the thing with the dwarf and the women chained in the basement. It's up to Amir's friend Bob and wife Tracey to try and salvage this tale.
A brilliant surgeon encases his dead son's brain in a large robot body, with unintended results...