Los Reyes County, Arizona. Leland, a retired lawman, works with Wallace, the new sheriff who replaces him, when a vicious hit man, sent by a Mexican drug cartel, threatens their border small town.
A former gunslinger is forced to take up arms again when he and his cattle crew are threatened by a corrupt lawman.
Before he was killed by Mark Foster's men, Bud Lawton willed part ownership in his ranch to Hoppy and his two pals. When the three arrive they find a fake posing as Lawton. When they expose the imposter, Foster gets the Sheriff to jail them for Lawton's murder.
Hoppy and new sidekick California Carlson head to California to help out Lucky Jenkins.
Hoppy, California and Johnny partner up with brother and sister ranch owners, two of several who are having their access to water blocked by a dam owned by a greedy merchant in town, who is intent on driving them out and taking their land for himself.
Julie's husband has been murdered and land agents want her to sign away her property rights. Hoppy warns against this but she does so anyway. It looks as though she will be unable to deliver the timber called for in her agreement. Hoppy has to make the lumber deal happened and solve the murder.
Hopalong Cassidy, boss of the Bar 20 ranch in Texas, rides down the Camino Real in the New Mexico cattle country near Alamogordo, in response to an urgent message from his lifelong sweetheart, Nora Blake, who is in serious trouble. Before he and his saddlemates, "Lucky" Jenkins and "Pappy", can reach her ranch, they are stopped by Clay Allison, a cattle-rustler who is in almost complete control of the district, and wants to extend his holdings by seizing Nora's cattle and driving her out. Seeing Cassidy as a menace to his plans, he has him arrested on a trumped-up charge. Cassidy and his pals shoot their way out of the trouble and reach Nora;s ranch where they learn that Allison's henchmen have murdered her foreman, Tom Dillon, and Allison has sent for a crew of outlaws on the Texas border.
Wrongfully imprisoned for a crime he didn't commit, Minnesota Clay seeks revenge on the man who withheld evidence at his trial. There is a problem however, he is going blind.
Former Marshal Will Kane and his Amish bride, Amy, return to Hadleyville a year after he resigned and find the town in the grip of a bounty-hunting marshal and his two trigger-happy deputies.
John and George McIntire are a couple of naive brothers who travel to a lawless western town to see their father. The bumbling siblings get themselves into big trouble after they beat up a member of a gang of extortionists. Fortunately, a mysterious roving gunfighter decides to help the guys out of their jam.
A railroad investigator discovers that there's more than meets the eye to a series of reported Indian attacks against the railroad.