In early 20th-century Montana, Col. William Ludlow lives on a ranch in the wilderness with his sons, Alfred, Tristan, and Samuel. Eventually, the unconventional but close-knit family are bound by loyalty, tested by war, and torn apart by love, as told over the course of several decades in this epic saga.
When three women living on the edge of the American frontier are driven mad by harsh pioneer life, the task of saving them falls to the pious, independent-minded Mary Bee Cuddy. Transporting the women by covered wagon to Iowa, she soon realizes just how daunting the journey will be, and employs a low-life drifter, George Briggs, to join her. The unlikely pair and the three women head east, where a waiting minister and his wife have offered to take the women in. But the group first must traverse the harsh Nebraska Territories marked by stark beauty, psychological peril and constant threat.
Abahachi, Chief of the Apache Indians, and his blood brother Ranger maintain peace and justice in the Wild West. One day, Abahachi needs to take up a credit from the Shoshone Indians to finance his tribe's new saloon. Unfortunately Santa Maria, who sold the saloon, betrays Abahachi, takes the money and leaves. Soon, the Shoshones are on the warpath to get their money back, and Abahachi is forced to organize it quickly.
Chon Wang, a clumsy imperial guard, trails Princess Pei Pei when she's kidnapped from the Forbidden City and transported to America. Wang follows her captors to Nevada, where he teams up with an unlikely partner, outcast outlaw Roy O'Bannon, and tries to spring the princess from her imprisonment.
Native American business partners, Marty and Jess, embark on a journey to the American Southwest to shoot a film. The fun lasts until Jess vanishes without a trace leaving a worried Marty to deal with her past, false allegations and racism while trying to find her friend.
An elderly rodeo rider becomes mentor to a young man attempting to make his own name in the business.
Fred Engel's father is murdered by Colonel Brinkley in order to acquire a treasure map, however the Colonel only acquires half of it, the other half as held by Mrs. Butler. Discovering the scene of the crime, Old Shatterhand and Winnetou help Fred bring his father's murderer to justice and locate the treasure of Silver Lake.
Farsighted Falcon, chief of the Lakota, seeks refuge in the Black Hills with his wife Blue Hair and two warriors, sole survivors of their tribe. When they are attacked by the outlaw Bashan, Falcon strikes out for the town of Tanglewood to take on Bashan's boss, mining magnate Harrington.
Rollins' gang wants to grab land by inciting the settlers in a war against the Indians but Winnetou and Old Shatterhand try to keep the peace, until Rollins frames Winnetou up for the murder of Jicarilla Chief's son.
The neighbors of a frontier family turn on them when it is suspected that their beloved adopted daughter was stolen from the Kiowa tribe.