While the Civil War rages on between the Union and the Confederacy, three men – a quiet loner, a ruthless hitman, and a Mexican bandit – comb the American Southwest in search of a strongbox containing $200,000 in stolen gold.
As the railroad builders advance unstoppably through the Arizona desert on their way to the sea, Jill arrives in the small town of Flagstone with the intention of starting a new life.
At the beginning of the 1913 Mexican Revolution, greedy bandit Juan Miranda and idealist John H. Mallory, an Irish Republican Army explosives expert on the lam from the British, fall in with a band of revolutionaries plotting to strike a national bank. When it turns out that the government has been using the bank as a hiding place for illegally detained political prisoners - who are freed by the blast - Miranda becomes a revolutionary hero against his will.
The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.
Two bounty hunters both pursue a brutal and sadistic bandit El Indio who has a massive bounty on his head.
Lucky Luke becomes the Sheriff of Daisy Town and runs out all the criminals. Then the Dalton brothers arrive and try to get the Indians to break the peace treaty and attack the town.
Jack Beauregard, an ageing gunman of the Old West, only wants to retire in peace and move to Europe. But a young gunfighter, known as "Nobody", who idolizes Beauregard, wants him to go out in a blaze of glory. So he arranges for Jack to face the 150-man gang known as The Wild Bunch and earn his place in history.
An IRA operative escapes to the Americas and teams up with a circus singer to create a popular vaudeville act. When the singer falls for a rebel, they leave the circus behind to become fierce revolutionaries.
The two brothers Trinity and Bambino are exchanged by two federal agents and take advantage of the situation to steal a huge booty hidden in a monastery by a gang of outlaws.
When Sheriff Bill marries, he moves to another village to lead a more peaceful life. His replacement is killed by Colorado Charlie and his gang. The town sends for Bill, who returns unarmed because his wife has hidden his gun. When Colorado Charlie demands a shoot-out, Bill's wife relents and gives him back his weapon After Bill kills the bandit, his wife agrees to his return as sheriff.
Richard le Noir, disguised as a woman, helps free the local girls of the California town of Harriba Lannana, from enslavement at a local brothel called the Golden Saloon.