In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.
When an asteroid threatens to collide with Earth, NASA honcho Dan Truman determines the only way to stop it is to drill into its surface and detonate a nuclear bomb. This leads him to renowned driller Harry Stamper, who agrees to helm the dangerous space mission provided he can bring along his own hotshot crew. Among them is the cocksure A.J. who Harry thinks isn't good enough for his daughter, until the mission proves otherwise.
Eighties teenager Marty McFly is accidentally sent back in time to 1955, inadvertently disrupting his parents' first meeting and attracting his mother's romantic interest. Marty must repair the damage to history by rekindling his parents' romance and - with the help of his eccentric inventor friend Doc Brown - return to 1985.
As trouble brews on the space trading colony of Iceworld, the Doctor and Mel encounter their sometimes-ally Sabalom Glitz and a new friend who goes by the name "Ace".
The Doctor and Mel go for a holiday trip to Shangri-La aboard a Nostalgia Tours bus, only to get dragged into the battle against genocide of their fellow passenger Delta, a Chimeron Queen fleeing from the Bannermen who wish to make her species extinct.
The Rani has returned with another malicious scientific scheme. Taking advantage of the post-regenerative trauma the recently regenerated and unstable Doctor is going through, she hopes to achieve control of an approaching asteroid composed entirely of strange matter. Can the Doctor figure out he is being used for the Rani's evil experiment, and what is behind the door the Rani won't allow him past?
The Time Lords send the Doctor and Jo on a mission to deliver a sealed message pod to an unknown party aboard a Skybase orbiting the planet Solos in the 30th century. They are caught quickly in a power struggle between the cruel Marshal of Solos and the young Solonian Ky over the future of Solos - a future that hinges on the contents of the message.
The Master, in the guise of Professor Thascalos, has constructed at the Newton Institute in Wootton a device known as TOMTIT - Transmission Of Matter Through Interstitial Time - to gain control over Kronos, a creature from outside time. The creature is summoned but proves to be uncontrollable.
The Doctor and Jo find themselves trapped inside an alien peepshow machine which showman Vorg and his assistant Shirna have brought to amuse the populace of the planet Inter Minor. Can they escape Vorg and the ferocious Drashigs?
In the 26th century, the Doctor and Jo uncover a plot by the Master to provoke an interplanetary war between Earth and Draconia.
On the jungle planet Spiridon, the Doctor, Jo and a Thal group find a slumbering army of Daleks ready to awaken.